About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onLinkedIn,Facebook,Instagram,XandYouTube.

For thePrincipal Research Scientist I position, we are seeking a highly motivated, experienced analytical scientist to be an Analytical Project Leader in New Chemical Entities (NCEs) drug substance and drug product in both preclinical and clinical programs. The candidate should have extensive expertise within an R&D environment with a fit for purpose mindset. Expertise with synthetic molecules in solid oral dosage forms is expected. Additional experience with lipid nanoparticles highly desired.

The qualified candidate should be able to conceive, execute and communicate novel strategies that achieve project goals and department imperatives across a multi-disciplinary research and development organization. They must have experience as an analytical project lead and demonstrate a capability to manage CMC deliverables relevant to early-phase clinical development and on discovery programs with pre-clinical candidate compounds.

The qualified candidate must foster productive collaborations within the global Analytical R&D organization and with R&D cross-functional partners such as Discovery, Pre-Clinical Safety, Process Chemistry, Process Engineering, Molecular Profiling and Drug Delivery, Drug Product Development, and Quality Assurance and CMC-Regulatory.

The qualified candidate will be based at the AbbVie Bioresearch Center in Worcester, MA. However, they must be able to provide 50% on-site support at the AbbVie Bioresearch Center in Worcester, MA and 50% on-site support at the AbbVie Cambridge Crossing site in Cambridge, MA according to project needs.

Responsibilities:

• Apply analytical separation and detection modes for complex impurity profiling of pharmaceutical products to advise the selection of molecules with properties suitable for development.
• Generate new scientific proposals and lead those efforts. Anticipate and critically

evaluate scientific or regulatory advances or competitive threats and respond with

appropriate new strategies.

• Demonstrate scientific initiative and creativity in research or development activities and maintain a high level of productivity in the lab.
• Embraces the ideas of others, nurtures innovation and manages innovation to reality.
• Raises the bar and is never satisfied with the status quo.
• Understand and comply with AbbVie safety, quality and regulatory policies and government regulations.

• Bachelors, Masters, or Ph.D. in Analytical Chemistry typically with a minimum of 14 (BS), 12 (MS), or 6 (Ph.D.) years related industry experience.
• Strong technical background in analytical chemistry, excellent analytical problem-solving skills. Capable of independently developing and troubleshooting analytical methods.
• Demonstrated leadership with solving technical challenges across therapeutic modalities, specifically the lipid nanoparticle (LNP) and small molecule spaces.
• Demonstrated experience with a variety of mass spectrometry (MS) instrumentation and applications for structure elucidation and trace quantitation is highly desired.
• Fundamental understanding and working knowledge of various analytical techniques including HPLC, UPLC, GC, DSC, TGA, DVS, PXRD, NMR, dissolution.
• Familiarity with the role that physicochemical properties play in drug delivery and formulation design.
• Working knowledge of typical formulation approaches and routes of administration (i.e. IV, SC, IP, PO) across multiple species.
• Knowledge of preclinical and clinical formulation development principles relevant to lipid nanoparticle formulations.
• Demonstrate creative out-of-the-box thinking to solve difficult problems
• Self-motivated, hard-working, detail-oriented individual able to work in a fast-paced team environment.
• High-quality written and oral communication skills and ability to interact effectively with interdisciplinary scientists and engineers.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.

• This job is eligible toparticipatein our long-term incentiveprograms.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company's sole andabsolutediscretion unless and until paid andmay bemodifiedat the Companys sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visithttps://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html